Description
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM) 1. Inhibits ER stress-induced neuronal damage 2. Reduces brain PKR activation in vivo 3. Prevents apoptosis and IL-1 Beta production in an acute excitotoxic and neuroinflammatory rat model 4. Prevents Beta-amyloid peptide-induced inflammation in primary murine mixed co-cultures 5. Cell permeable.
C16
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM) 1. Inhibits ER stress-induced neuronal damage 2. Reduces brain PKR activation in vivo 3. Prevents apoptosis and IL-1 Beta production in an acute excitotoxic and neuroinflammatory rat model 4. Prevents Beta-amyloid peptide-induced inflammation in primary murine mixed co-cultures 5. Cell permeable.
C16
